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Pre-Clinical Animal data
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Preclinical Studies Key Findings
- No evidence of vasoconstriction in heart, brain and kidney
- Increased vascular resistance only in skeletal muscle
Myocardinal infarction (on the left) and saved heart tissue (right) after reperfusion with saline and modified hemoglobin O2 carrier (m-HPAOC)
Blue stain – normal tissue
Red stain – areas at risk
Yellow stain – infarction – dead heart tissue
HBOC-201 - modified hemoglobin O2 carrier (m-HPAOC)
Middle Cerebral Artery Blockade Model in Rats
Comparison Between Perfused and Unperfused Brains
Top sections are perfused
Trauma : Preclinical Models
Substantial preclinical database
- 41 trauma-related studies (mainly swine)
- 23 Hemorrhagic Shock (HS) studies (+ TBI)
Mortality: reduced in all models combined
- HBOC-201 12% vs. control 47%, p < 0.0001
- Group difference 35%
- Reduction 75% (effect size)
Mortality: dramatically reduced in severe HS models
- HBOC-201 17% vs. control 93%, p < 0.0001
- Group difference 76%
- Reduction 82% (effect size)
Organ salvage with m-HPAOC perfusion
A. Liver#5 before perfusion
B. Liver#5 after 1-minute HBOC-201 perfusion
This liver was poorly perfused in situ and on the back table during the retrieval process, however performed very well and a homogenous perfusion was achieved almost immediately, helped by the low viscosity of the fluid.
C. Liver #1 before perfusion
D. Liver #1 after 1-minute HBOC-201 perfusion
Despite the severely steatotic nature of the graft, a homogenous perfusion was still achieved shortly after almost 7 hours of cold storage.
M-HPAOC Functions
- When a person has a stroke and traumatic brain injury M-HPAOC will provide oxygenation for the injured areas and to the whole body in case of cardiogenic shock and massive bleeding.
- Serious organ injury occur when patient on mechanical ventilator doesn’t receive sufficient perfusion of the peripheral tissue. M-HPAOC prevent such injury and save more organs.
- During transportation M-HPAOC can provide adequate organ perfusion for the long period of time (12+ hours for heart and liver, and 4 days for kidney) without ischemic insult. The support of oxygen distribution at lower temperature is the unique and proven new finding to limit programmed cell death. This results in long-term sustainability of the organ and their acceptance for usage.
Medical Device For Organ Preservation
Oxy-Rx™, to be registered as a medical device indicated for prolong
- preservation of organs for transplant during transport or storage
- extracorporeal circulation
For further information on OXY-Rx™ please contact us.
We would be happy to discuss it further.
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