About Hemoglobin

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What is Hemoglobin


The Oxygen Carrying Protein

Hemoglobin is found in the red blood cells (RBC) and is the actual protein component that carries oxygen in the blood stream.

Oxy-Rx™ is 1/5000 RBC's size, this stablizied hemoglobin can go throough obstructed blood vessels and end-size capillaries to supply oxygen to tissues in need.

Matinicus Pharma harvests blood from cows of traceable source, extract and ultra purify the heme out of the heme-o-globin protein with proprietary technology to carbohydrate and create lifesaving products which are universally compatible, portable and room-temperature stable.

The stabilized Heme-corbohydrate is kept in dry or liquid form.


Product Characteristics


  • Delivers oxygen immediately upon infusion​
  • Long shelf life at liquid form​
  • 3 years at room temperature​
  • Shelf life in dry form, INDEFINITELY.​
  • Universally compatible. Non immunogenic.​
  • Small molecule (<1/5000th the size of a RBC)​
  • Low viscosity​

In mammals, tissue oxygentation is regulated by a complex between the heart, the lungs and the circulating blood, which contains red blood cells suspended in plasma (the fluid part of blood). Oxygen is on-loaded into red blood cells in the lungs, transported throughout the body via the circulatory system, and off-loaded from red blood cells to tissues and organs.

Hemoglobin, a protein encapsulated within red blood cells, is the tetrameric (four-part) molecule responsible for carrying and releasing oxygen.

Oxy-Rx™ - "Natural" Modified-hemoglobin Protein Active Oxygen Carrier

Without product - stroke - brain damage

With product - continuous oxygen delivery - no brain damage

Oxy-Rx™ Characteristics

Hemoglobin

Bovine derived, Glutaraldehyde polymerized

Appearance

Deep Purple

Polymeric Product Average Molecular Weight

250 kD

pH

7.6-7.9

Ion Concentration                                    Na                                                                       Cl                                                                       K                                                                         Ca


145-160 mEq

105-120 mEq

3.5-5.5 mEq

0.5-1.5 mEq

Osmolarity

290-310 mOsm/Kg

Hemoglobin Concentration

13.0 g/dL

Methemoglobin

<5%

Endotoxin

<0.02 EU/mL

Colloid Osmotic Pressure

25 mmHg

Viscosity (37° C)

1.3 centipoise

P50

38 mmHg

Phospholipids

<0.1 mg/mL

Reconstitution

None required

Administration

Peripheral or central vein

Storage requirements

Room temperature up to 37° C for three years

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For further information on OXY-Rx™ please contact us.

We would be happy to discuss it further.

0207 034 3300

We’d like to hear from you

Fitzrovia Hospital,

13-14 Fitzroy Square London, W1T 6AH

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About

Matinicus Pharma provides life-sustaining support and resuscitation for local (tissue, organ) and systemic (body) oxygen deprivation.

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Contact

0207 034 3300


Fitzrovia Hospital,

13-14 Fitzroy Square London, W1T 6AH